Chapters

00:00 Introduction to the Genesis mission and guest background

02:01 Dan’s diverse scientific background and policy experience

07:08 Overview of the Genesis mission and its recent expansion

11:10 The importance of focus and funding for the mission

15:11 Challenges of broad AI initiatives and strategic focus

19:52 Communication strategies for AI in science to the public and Congress

25:08 Platforms versus challenges in AI research and development

30:00 Balancing basic research with targeted AI applications

34:53 Concluding thoughts on focus, communication, and the future of AI in science

Chapters

00:00 Introduction and episode overview

01:00 Guest introduction: Josh New and SeedAI

02:05 Josh’s path from tech policy to AI for science

03:23 The rise of AI in scientific research

05:14 Changing conversations in AI policy

07:43 Rapid evolution of AI and policy challenges

08:35 The impact of AI saturation on scientific workflows

12:00 Unlocking AI’s potential versus steering its direction

14:02 Decentralized science and policy intervention

17:28 Reimagining research labs with AI and automation

20:55 Funding models and data infrastructure for AI-driven science

23:07 Lessons from the Human Genome Project and big science

29:45 The ASN model as connective tissue in AI and science

34:30 Closing thoughts and call to action

Episode Resources

SeedAI - https://seedai.org

AlphaFold - Protein structure prediction - https://deepmind.com/research/highlighted-research/alphafold

Human Genome Project - https://www.genome.gov/human-genome-project

ASN Coalition - Accelerate Science Now - https://acceleratesciencenow.com/

In this trailer, host Zhane Yamin introduces State Space — a new show exploring the ideas shaping science acceleration, AI for science, and meta-science. Drawing on the concept of a "state space" (the mathematical universe of every possible configuration a system can take), Zhane frames the show's core question: how do we find the right variables — the right basis — to cut through the noise and make sense of a research ecosystem that's evolving faster than ever under AI?

Each episode of State Space will feature a conversation with a leading voice in science acceleration, offering a new angle on how science moves faster in an AI-native era.

In this episode:

- What a "state space" is, and why it's a useful lens for thinking about complex systems — from a mass on a spring to a neural network to a game of chess

- Why the scientific research ecosystem is itself a kind of state space, full of decades of accumulated ideas and new AI-driven breakthroughs

- What to expect from the show: conversations at the intersection of science acceleration, AI for science, and meta-science

Host: Zayn Yaman, Science Policy Fellow at Seed AI

About the show: State Space is powered by the Accelerate Science Now Coalition, a Seed AI project.